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- Title
Identification of a Major Susceptibility Locus on Chromosome 6p and Evidence for Further Disease Loci Revealed by a Two Stage Genome-Wide Search in Psoriasis.
- Authors
Trembath, Richard C.; Lee Clough, R.; Rosbotham, Jane L.; Jones, Andrew B.; Camp, Richard D. R.; Frodsham, Angela; Browne, Julie; Barber, Ruth; Terwilliger, Joseph; Mark Lathrop, G.; Barker, Jonathan N. W. N.
- Abstract
Psoriasis is a common chronic inflammatory disorder of the skin. To further understand the pathogenesis of psoriasis we have chosen to investigate the molecular genetic basis of the disorder. We have used a two-stage approach to search the human genome for the location of genes conferring susceptibility to psoriasis, using a total of 106 affected sibling pairs identified from 68 independent families. As over a third of the extended kindreds included affected relatives besides siblings, in addition to an analysis of allele sharing between affected sibling pairs, a novel linkage strategy was applied that extracts full non-parametric information. Four principal regions of possible linkage were identified on chromosomes 2, 8, 20 (p <0.005) and markers from the MHC region at 6p21 (p <0.0000006) for which significant evidence of linkage disequilibrium was also observed (p<0.00002). Whilst data from limited case control associations exist to implicate the MHC, the results of this genome wide analysis demonstrate that, at least in the population studied, a gene or genes located within the MHC and close to the class 1 HLA loci, represent the major determinant of the genetic basis of psoriasis.
- Publication
Human Molecular Genetics, 1997, Vol 6, Issue 5, p813
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/6.5.813