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- Title
Do mitochondrial K<sub>ATP</sub> channels serve as triggers rather than end-effectors of ischemic preconditioning's protection?
- Authors
Downey, James M.; Cohen, Michael V.
- Abstract
The article discusses the role of mitochondrial KATP channels in ischemic preconditioning protection. We also became interested in mKATP effect in preconditioning. Indeed, using infarct size as the end-point the researchers found that diazoxide mimicked preconditioning and that 5-hydroxydecanoate blocked preconditioning's anti-infarct effect. The researchers perception of the role of free radicals in the cell is slowly changing from one of vicious killer to that of a utilitarian signal transduction element. However, the search is hampered by the fact that the researchers do not know what the actual lethal event is in the ischemic myocardium.
- Subjects
ISCHEMIA; MITOCHONDRIAL membranes; MYOCARDIUM; GENETIC transduction; BLOOD circulation disorders; FREE radicals; CARDIAC research
- Publication
Basic Research in Cardiology, 2000, Vol 95, Issue 4, p272
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s003950070045