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- Title
Relay catalysis enabled tandem reaction of 2-indolylmethanols for the construction of 3,3'-bisindole skeletons.
- Authors
LIU Kaiyue; MA Xiaofang; YANG Shuang; CHEN Yuyu; XU Chengye; ZHANG Yuchen; SHI Feng
- Abstract
Herein, we have developed a new strategy for the construction of 3,3'-bisindole skeletons. This strategy makes use of the tandem reaction of 2-indolylmethanols with o-aminophenylacetylenes enabled by the relay catalysis of palladium/Brønsted acid, thus affording structurally diversified 3,3'-bisindoles in generally high yields (33 examples, up to 98% yield). This reaction can be performed in gram scale and the products can undergo synthetic transformation. Moreover, control experiments elucidated the role of the relay catalysis of palladium/Brønsted acid in controlling the reactivity of this tandem reaction, This re- action not only adds a new example to relay catalytic tandem reactions of 2-indolylmethanols, but also pro- vides an atom-economic method for the synthesis of 3,3'-bisindoles.
- Subjects
CATALYSIS; ACIDS
- Publication
Journal of Molecular Science, 2024, Vol 40, Issue 1, p25
- ISSN
1000-9035
- Publication type
Article
- DOI
10.13563/j.cnki.jmolsci.2023.08.016