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- Title
Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer.
- Authors
Karran, Peter; Attard, Natalie
- Abstract
Thiopurines have diverse clinical applications and their long-term use as anti-rejection drugs in transplant patients has been associated with a significantly increased risk of various types of cancer. Although they are slowly being replaced by a new generation of non-thiopurine immunosuppressants, it is anticipated that their use in the management of inflammatory and autoimmune diseases will continue to increase. Therapy-related cancer will remain a potential consequence of prolonged treatment for these generally non-life-threatening conditions. Understanding how thiopurines contribute to the development of cancer will facilitate clinical decisions about the potential risks to patients of long-term treatment for chronic inflammatory disorders.
- Subjects
CANCER treatment; THERAPEUTIC equivalency in drugs; GRAFT rejection; IMMUNOSUPPRESSIVE agents; CHRONIC diseases
- Publication
Nature Reviews Cancer, 2008, Vol 8, Issue 1, p24
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc2292