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- Title
Mushroom consumption and incident risk of prostate cancer in Japan: A pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study.
- Authors
Zhang, Shu; Sugawara, Yumi; Chen, Shiuan; Beelman, Robert B.; Tsuduki, Tsuyoshi; Tomata, Yasutake; Matsuyama, Sanae; Tsuji, Ichiro
- Abstract
In vivo and in vitro evidence has shown that mushrooms have the potential to prevent prostate cancer. However, the relationship between mushroom consumption and incident prostate cancer in humans has never been investigated. In the present study, a total of 36,499 men, aged 40–79 years, who participated in the Miyagi Cohort Study in 1990 and in the Ohsaki Cohort Study in 1994 were followed for a median of 13.2 years. Data on mushroom consumption (categorized as <1, 1–2 and ≥3 times/week) was collected using a validated food frequency questionnaire. Cox proportional hazards regression analysis was used to estimate multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) for prostate cancer incidence. During 574,397 person‐years of follow‐up, 1,204 (3.3%) cases of prostate cancer were identified. Compared to participants with mushroom consumption <1 time/week, frequent mushroom intake was associated with a decreased risk of prostate cancer (1–2 times/week: HRs [95% CIs] = 0.92 [0.81, 1.05]; ≥3 times/week: HRs [95% CIs] = 0.83 [0.70, 0.98]; p‐trend = 0.023). This inverse relationship was especially obvious among participants aged ≥50 years and did not differ by clinical stage of cancer and intake of vegetables, fruit, meat and dairy products. The present study showed an inverse relationship between mushroom consumption and incident prostate cancer among middle‐aged and elderly Japanese men, suggesting that habitual mushroom intake might help to prevent prostate cancer. What's new? Mushrooms have long been used as a source of food and medicine in Asian cultures and are suspected of possessing anticancer properties. Whether the consumption of mushrooms can help prevent cancer, however, remains unknown. In the present study, among men who enrolled in the Miyagi and Ohsaki cohort studies in Japan in 1990 and 1994, respectively, long‐term follow‐up indicates that frequent mushroom consumption is associated with reduced prostate cancer risk. The effect was especially pronounced in men age 50 or older and in those with relatively low in fruit and vegetable intake and high in meat and dairy intake.
- Subjects
JAPAN; PROSTATE cancer; COHORT analysis; MUSHROOMS; ASIAN medicine; TUMOR classification
- Publication
International Journal of Cancer, 2020, Vol 146, Issue 10, p2712
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.32591