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- Title
The immunoregulatory effects of Qa-1.
- Authors
Linrong Lu; Werneck, Miriam B. F.; Cantor, Harvey
- Abstract
The immune system is not only well equipped to control infections but also tightly controlled to prevent autoimmune disease. Despite the negative selection of T-cell clones in the thymus, mature T cells capable of recognizing self-antigens are present in every individual. Several types of specialized regulatory cells maintain homeostasis and prevent expansion of autoreactive T cells. In this issue of Immunological Reviews, the role of CD4+ regulatory T cells is extensively discussed. Suppression of T-cell responses by CD8+ T cells has received less attention. Here, we review research on Qa-1-restricted CD8+ regulatory T cells. We focus on the role of this class Ib major histocompatibility complex (MHC) molecule in both CD8+ regulatory T-cell activity and protection of activated T cells.
- Subjects
T cells; LYMPHOCYTES; IMMUNOREGULATION; IMMUNE system; AUTOIMMUNE diseases
- Publication
Immunological Reviews, 2006, Vol 212, Issue 1, p51
- ISSN
0105-2896
- Publication type
Article
- DOI
10.1111/j.0105-2896.2006.00418.x