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- Title
One cell, one antibody: prelude and aftermath.
- Authors
Nossal, G.J.V.
- Abstract
This essay seeks to summarize one scientist's pilgrim's progress through the world on antibody formation, attempting to capture the flavor of problems as encountered within their times. It seeks to portray a world where the direct template hypothesis ruled the day,where the function of lymphocytes was unknown, let alone the difference between T and B cells, and where antibody genes were but a dream. Struggles to establish the credential of the clonal selection hypothesis are presented in some detail, as are the implications which followed the 'one cell--one antibody' discovery. The other two main preoccupations of the author are presented more briefly, namely the essential features of the germinal center and the cellular basis of immunological tolerance within the B lymphocyte compartment. Naturally, the experiments become more sophisticated as both knowledge and technology mature. A continuing thread within the unfolding story is that one must not shy away from developing new techniques when problems demand them.
- Subjects
IMMUNOGLOBULINS; T cells; B cells; LYMPHOCYTES
- Publication
Immunological Reviews, 2002, Vol 185, Issue 1, p15
- ISSN
0105-2896
- Publication type
Article
- DOI
10.1034/j.1600-065X.2002.18503.x