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- Title
Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis.
- Authors
Gao, Yun-Rong; Feng, Na; Chen, Tao; Li, De-Feng; Bi, Li-Jun
- Abstract
Rv0880 from the pathogen Mycobacterium tuberculosis is classified as a MarR family protein in the Pfam database. It consists of 143 amino acids and has an isoelectric point of 10.9. Crystals of Rv0880 belonged to space group P1, with unit-cell parameters a = 54.97, b = 69.60, c = 70.32 Å, α = 103.71, β = 111.06, γ = 105.83°. The structure of the MarR family transcription regulator Rv0880 was solved at a resolution of 2.0 Å with an Rcryst and Rfree of 21.2 and 24.9%, respectively. The dimeric structure resembles that of other MarR proteins, with each subunit comprising a winged helix-turn-helix domain connected to an α-helical dimerization domain.
- Subjects
MYCOBACTERIUM tuberculosis; PROTEINS; GENETIC databases; AMINO acids; DIMERS
- Publication
Acta Crystallographica: Section F, Structural Biology Communications, 2015, Vol 71, Issue 6, p741
- ISSN
2053-230X
- Publication type
Article
- DOI
10.1107/S2053230X15007281