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- Title
NMR Meets Tau: Insights into Its Function and Pathology.
- Authors
Lippens, Guy; Landrieu, Isabelle; Smet, Caroline; Huvent, Isabelle; Gandhi, Neha S.; Gigant, Benoît; Despres, Clément; Haoling Qi; Lopez, Juan
- Abstract
In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate phosphorylation patterns by different kinases, and its non-destructive character has allowed functional assays with the same samples. Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function.
- Subjects
TAU proteins; PHOSPHORYLATION; NUCLEAR magnetic resonance spectroscopy; MICROTUBULES; POST-translational modification
- Publication
Biomolecules (2218-273X), 2016, Vol 6, Issue 2, p28
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom6020028