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- Title
SECONDARY RENAL AMYLOIDOSIS.
- Authors
OZCAN, AYHAN; YAVAN, IBRAHIM; UNAL, HILMI UMUT
- Abstract
OBJECTIVE: Amyloidosis is a condition caused by the accumulation of extracellular non-soluble fibrillary proteins, which are responsible for tissue damage. The most common form of secondary amyloidosis is AA (amyloid-associated) amyloidosis. AA amyloidosis is mostly encountered in the Mediterranean region, while primary amyloidosis (AL amyloidosis) is frequent in Western countries. Aim of this study is to determine the proportion of comorbidities associated with AA amyloidosis, and to examine its histological and immunohistochemical features. MATERIAL AND METHOD: This retrospective analysis included 47 cases diagnosed as AA amyloidosis in between the years of 2002-2010. Slides from all cases were stained with Kongo red, as well as with anti-AA antibody, immunohistochemically. RESULTS: Among the comorbidities associated with AA amyloidosis, Familial Mediterranean Fever (FMF) (n=19), rheumatoid arthritis (n=1), Takayasu arteritis (n=1) and ankylosing spondylitis (n=1) were determined. At the time of histopathological evaluation, 25 cases had no previous history and/or diagnosis. The amyloid deposits were found in the glomeruli, interstitium and blood vessels. In all cases, apple-green birefringence of Kongo-red stained areas under polarized light has been demonstrated. Anti-AA antibody immunoreactivity was observed in all cases. CONCLUSION: Among the diseases associated with secondary renal amyloidosis, FMF was the most frequent one in our series. Renal amyloidosis, on the other hand, was the most common and most serious consequent with a poor outcome. To prevent serious damage of the kidney, early diagnosis is crucial. Biopsy is still gold standard for both the accurate diagnosis and the follow-up of the disease.
- Publication
Balkan Military Medical Review, 2013, Vol 16, p178
- ISSN
1107-6275
- Publication type
Article