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- Title
Candida-reactive T cells for the diagnosis of invasive Candida infection of the lumbar vertebral spine.
- Authors
Koehler, Felix C.; Cornely, Oliver A.; Wisplinghoff, Hilmar; Chang, De‐Hua; Richter, Anne; Koehler, Philipp
- Abstract
Invasive Candida infection is the fourth most common bloodstream infection. Blood cultures are the current gold standard diagnostic method, however, false negatives remain a clinical challenge. We developed a new technique measuring Candida-reactive T cells as diagnostic read-out for invasive Candida infection. In a pilot study, we followed the treatment course of a patient with an invasive Candida infection of the lumbar vertebral spine. We present the case of a 56-year-old patient with HIV-associated Burkitt lymphoma who developed septic shock during chemotherapy-induced neutropenia. For the first time, we provide flow cytometry-based diagnostics with Candida-reactive T cells for invasive candidiasis with comprehensive MRI imaging. The Candida-reactive T cell assay has potential to complement current diagnostic assays for invasive Candida infection and thus to support targeted treatment.
- Subjects
T cells; CANDIDIASIS; LUMBAR vertebrae; BLOOD diseases; BURKITT'S lymphoma
- Publication
Mycoses, 2018, Vol 61, Issue 1, p48
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/myc.12696