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- Title
Serum brain-derived neurotrophic factor (BDNF) levels in attention deficit-hyperactivity disorder (ADHD).
- Authors
Scassellati, Catia; Zanardini, Roberta; Tiberti, Alessandra; Pezzani, Marco; Valenti, Vera; Effedri, Paola; Filippini, Elena; Conte, Stefano; Ottolini, Alberto; Gennarelli, Massimo; Bocchio-Chiavetto, Luisella
- Abstract
It has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit-hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age-sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t = −0.26, p = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.
- Subjects
ATTENTION-deficit hyperactivity disorder; ENZYME-linked immunosorbent assay; FISHER exact test; NEUROPSYCHOLOGICAL tests; RESEARCH funding; STATISTICAL hypothesis testing; T-test (Statistics); CONTROL groups; DATA analysis software; CILIARY neurotrophic factor; DESCRIPTIVE statistics
- Publication
European Child & Adolescent Psychiatry, 2014, Vol 23, Issue 3, p173
- ISSN
1018-8827
- Publication type
Article
- DOI
10.1007/s00787-013-0447-1