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- Title
DUBing down a tumour suppressor.
- Authors
Venkitaraman, Ashok R.
- Abstract
Monoubiquitination of the Fanconi anaemia protein FANCD2 is essential for its activity in DNA repair and tumour suppression. The recent identification of a specific de-ubiquitinating (DUB) enzyme for FANCD2 raises intriguing questions about how and why this tumour suppressor becomes deactivated.
- Subjects
TUMOR suppressor proteins; ANEMIA; DNA repair; BIOCHEMICAL genetics; BLOOD diseases; NUCLEIC acids
- Publication
Nature Cell Biology, 2005, Vol 7, Issue 4, p332
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb0405-332