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- Title
Magnetic Nanoparticles Supporting Bio-responsive T1/T2 Magnetic Resonance Imaging.
- Authors
Ellis, Connor M.; Pellico, Juan; Davis, Jason J.
- Abstract
The use of nanoparticulate systems as contrast agents for magnetic resonance imaging (MRI) is well-established and known to facilitate an enhanced image sensitivity within scans of a particular pathological region of interest. Such a capability can enable both a non-invasive diagnosis and the monitoring of disease progression/response to treatment. In this review, magnetic nanoparticles that exhibit a bio-responsive MR relaxivity are discussed, with pH-, enzyme-, biomolecular-, and protein-responsive systems considered. The ability of a contrast agent to respond to a biological stimulus provides not only enriched diagnostic capabilities over corresponding non-responsive analogues, but also an improved longitudinal monitoring of specific physiological conditions.
- Subjects
MAGNETIC resonance imaging; MAGNETIC nanoparticles; IRON oxide nanoparticles; PATIENT monitoring; SILICA nanoparticles; DIAGNOSIS
- Publication
Materials (1996-1944), 2019, Vol 12, Issue 24, p4096
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma12244096