We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Thyroid Dysfunctions Due to Immune Checkpoint Inhibitors: A Review.
- Authors
Sabbagh, Rawaa El; Azar, Nadim S; Eid, Assaad A; Azar, Sami T
- Abstract
Aim: Immune checkpoint inhibitors are anti-cancer drugs associated with adverse events that result from releasing the immune system against self-antigens while attacking cancer cells. Thyroid dysfunctions are among the most common associated adverse events. Materials and Methods: We conducted a systematic search of the literature in 2 databases: PubMed and Medline. Articles that reported thyroid adverse events of immune checkpoint inhibitors were reviewed. Thyroid disorders include hyperthyroidism and hypothyroidism and are most commonly seen with programmed cell death protein 1 and programmed death-ligand 1 inhibitors. Conclusions: Thyroid disorders are common side effects seen with check point inhibitors and are treated, depending on the clinical situation, by adequate hormonal replacement, thionamides, corticosteroids or observation only. The use of high dose corticosteroids has not been established as a treatment of thyroid toxicities. Thyroid function tests screening should be a part of baseline laboratory testing of all patients undergoing treatment with immune checkpoint inhibitors.
- Subjects
IMMUNE checkpoint inhibitors; PROGRAMMED death-ligand 1; DRUG side effects; THYROID gland; THYROID gland function tests; THYROTROPIN
- Publication
International Journal of General Medicine, 2020, Vol 13, p1003
- ISSN
1178-7074
- Publication type
Article
- DOI
10.2147/IJGM.S261433