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- Title
Clinical efficacy and safety of autologous stem cell transplantation for patients with ST-segment elevation myocardial infarction.
- Authors
Rong Li; Xiao-Ming Li; Jun-Rong Chen; Li, Rong; Li, Xiao-Ming; Chen, Jun-Rong
- Abstract
<bold>Purpose: </bold>The purpose of this study is to evaluate the therapeutic efficacy and safety of stem cells for the treatment of patients with ST-segment elevation myocardial infarction (STEMI).<bold>Materials and Methods: </bold>We performed a systematic review and meta-analysis of relevant published clinical studies. A computerized search was conducted for randomized controlled trials of stem cell therapy for STEMI.<bold>Results: </bold>Twenty-eight randomized controlled trials with a total of 1,938 STEMI patients were included in the present meta-analysis. Stem cell therapy resulted in an improvement in long-term (12 months) left ventricular ejection fraction of 3.15% (95% confidence interval 1.01-5.29, P<0.01). The 3-month to 4-month, 6-month, and 12-month left ventricular end-systolic volume showed favorable results in the stem cell therapy group compared with the control group (P≤0.05). Significant decrease was also observed in left ventricular end-diastolic volume after 3-month to 4-month and 12-month follow-up compared with controls (P<0.05). Wall mean score index was reduced significantly in stem cell therapy group when compared with the control group at 6-month and 12-month follow-up (P=0.01). Moreover, our analysis showed a significant change of 12-month infarct size decrease in STEMI patients treated with stem cells compared with controls (P<0.01). In addition, no significant difference was found between treatment group and control in adverse reactions (P>0.05).<bold>Conclusion: </bold>Overall, stem cell therapy is efficacious in the treatment of patients with STEMI, with low rates of adverse events compared with control group patients.
- Publication
Therapeutics & Clinical Risk Management, 2016, Vol 12, p1171
- ISSN
1176-6336
- Publication type
journal article
- DOI
10.2147/TCRM.S107199