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- Title
Çok İlaca Dirençli Providencia rettgeri Suşlarında Karbapenemaz Direnç Genlerinin Araştırılması.
- Authors
Demirbakan, Hadiye; Koçer, İpek; Özyurt, Özlem Koyuncu; Daloğlu, Cemile Aylin Erman
- Abstract
Objectives: Resistant bacterial pathogens are important causes of both community and healthcare associated infections. Providencia genus are Gram-negative bacilli in the Enterobacterales order, which mostly cause urinary tract infections. P. rettgeri is known to be a causative agent of catheter-related urinary system infections, especially in patients hospitalized in the intensive care unit recently. As with other resistant bacteria, the spread of hospital infections caused by Providencia species is mostly blamed on the failure of healthcare personnel to comply with infection control measures. Methods: In our study, a total of 22 multi-drug resistant P. rettgeri strains isolated from urine culture samples of 11 (50%) male and 11 (50%) female inpatients in our hospital between November 2017 and November 2021 were examined. Bacteria were evaluated for the presence of resistance genes by the mCIM, the BD Phoenix CPO detect panel, and conventional PCR. Results: By mCIM test, 18 (81.8%) strains were positive, three (13.6%) strains were negative, and one (4.6%) strain was indeterminate. All strains were identified as "class B carbapenemase producer" with the BD Phoenix CPO detection kit. With conventional PCR, OXA-48, IMP, VIM and KPC genes were not found to be positive in any of the strains, while all of the strains were found to be positive for the blaNDM gene. Conclusion: NDM is among class B carbapenemases and is common in the Enterobacterales family. P. rettgeri has recently been recognized as the key organism in the spread of NDM-1. It is very important to control the spread of this bacteria, which has resistance genes that can be transferred with plasmids against many antibacterials in hospitals. Our study shows that it is necessary to follow these strains in our hospital and take necessary infection control measures to prevent their spread.
- Publication
Dicle Medical Journal / Dicle Tip Dergisi, 2023, Vol 50, Issue 1, p74
- ISSN
1300-2945
- Publication type
Article
- DOI
10.5798/dicletip.1267126