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- Title
A-G-4G haplotype of PAI-1 gene polymorphisms −844 G/A, HindIII G/C, and −675 4G/5G is associated with increased risk of ischemic stroke caused by small vessel disease.
- Authors
Adamski, M. G.; Turaj, W.; Slowik, A.; Wloch-Kopec, D.; Wolkow, P.; Szczudlik, A.
- Abstract
Background – Plasminogen activator inhibitor type 1 (PAI-1) is the major inhibitor of fibrinolysis. It was reported that PAI-1 gene polymorphisms affected PAI-1 level and might therefore influence the risk of vascular diseases, including stroke. We studied the association of three common polymorphisms in PAI-1 gene (−844 G/A, −675 4G/5G, and HindIII G/C) with the odds of different causes of ischemic stroke. Methods – We studied 390 patients with ischemic stroke due to large vessel disease ( n = 117), small vessel disease ( n = 121), and cardioembolism ( n = 152) as well as 291 controls. The etiology of ischemic stroke was established using TOAST criteria. PAI-1 polymorphisms were genotyped with restriction fragment length polymorphism and single strand conformation polymorphism method. Results – A-G-4G haplotype of PAI-1 gene was found more frequently in stroke patients with small vessel disease than in control subjects (44.9% vs 35.7%; P = 0.02). No association was found between investigated genotype or allele frequencies and distinct causes of ischemic stroke. Conclusions – Our results demonstrate that A-G-4G PAI-1 gene haplotype is associated with increased risk of small vessel disease stroke, but this study does not support an association of −844 G/A, −675 4G/5G, and HindIII G/C PAI-1 gene polymorphisms with particular etiology of ischemic stroke.
- Subjects
PLASMINOGEN activators; INHIBITORS in Patients With Haemophilia (Book); FIBRINOLYSIS; GENETIC polymorphisms; VASCULAR diseases; ETIOLOGY of diseases
- Publication
Acta Neurologica Scandinavica, 2009, Vol 120, Issue 2, p94
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1111/j.1600-0404.2008.01127.x