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- Title
Clinical Significance of Anti-At<sup>a</sup>.
- Authors
Ramsey, G.; Sherman, L. A.; Zimmev, A. M.; Spies, W. G.; Sharma, L.; Arndt, P.; Garratty, G.
- Abstract
Ata is a high-frequency red blood cell (RBC) antigen. Anti-Ata has been reported in rare At(a-) black subjects. We report two cases of anti-Ata. A clinically significant anti-Ata was found in a 26-year-old black woman with systemic lupus erythematosus. The patient had a transfusion reaction with chills and nausea during a RBC survival study, and 95% of the radiolabeled At(a+) RBCs were destroyed within 3 h. A concurrently performed monocyte monolayer assay was strongly reactive. Anti-Ata thus can cause rapid hemolysis of transfused RBCs, but At(a-) donor units are extremely scarce in rare donor registries. A second patient at our hospital had anti-Ata which did not affect her newborn. She also had disease, insulin-dependent diabetes mellitus.
- Publication
Vox Sanguinis, 1995, Vol 69, Issue 2, p135
- ISSN
0042-9007
- Publication type
Article