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- Title
Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis.
- Authors
Franko, Jan; Ibrahim, Zuhaib; Gusani, Niraj J.; Holtzman, Matthew P.; Bartlett, David L.; Zeh, Herbert J.
- Abstract
BACKGROUND: Survival benefit of cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion was demonstrated by a prospective randomized trial for colorectal peritoneal carcinomatosis. Because of a recent substantial improvement in chemotherapy, the authors analyzed treatment options of colorectal carcinomatosis in the current era. METHODS: Consecutive patients with colorectal carcinomatosis treated by cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion from 2001 to 2007 were included. The controlgroup patients with carcinomatosis received contemporary chemotherapy alone. Overall survival was the primaryendpoint. RESULTS: All patients underwent systemic chemotherapy. The cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion group (n=67) was similar to the control group (n=38) in sex, tumor grade,site of tumor origin, T status, and N status. The control group was, however, older (59 vs 51 years; P<.001). Mediansurvival measured from the diagnosis of peritoneal disease was longer with cytoreductive surgery combined withhyperthermic intraperitoneal chemoperfusion (34.7 months vs 16.8 months; P<.001). Presence of liver metastasis wasa significant negative predictor of survival (hazard ratio, 2.13). CONCLUSIONS: The authors concluded that 1) contemporary chemotherapy is associated with prolonged survival among patients with carcinomatosis as compared withhistorical controls, and 2) addition of cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion to modern chemotherapy regimens may significantly prolong survival. Cytoreductive surgery combined withhyperthermic intraperitoneal chemoperfusion and systemic chemotherapy are not competitive therapies, and theyboth have a role in a multidisciplinary approach to patients with carcinomatosis.
- Subjects
COLON cancer; RECTAL cancer; DRUG therapy; METASTASIS; PERITONEAL cancer
- Publication
Cancer (0008543X), 2010, Vol 116, Issue 16, p3756
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.25116