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- Title
Unusual short-term complete response to two regimens of cytotoxic chemotherapy in a patient with poorly differentiated thyroid carcinoma.
- Authors
Crouzeix G; Michels JJ; Sevin E; Aide N; Vaur D; Bardet S; French TUTHYREF network; Crouzeix, Geneviève; Michels, Jean-Jacques; Sevin, Emmanuel; Aide, Nicolas; Vaur, Dominique; Bardet, Stéphane
- Abstract
<bold>Context: </bold>Treatment modalities for progressive iodine-refractory poorly differentiated thyroid carcinomas are not yet well defined. Molecular targeted therapy with multikinase inhibitors has recently shown promising results, and cytotoxic chemotherapy is generally considered of low efficacy.<bold>Objective: </bold>We report the case of a 57-yr-old woman with an advanced iodine-refractory poorly differentiated thyroid cancer who was treated sequentially between October 2006 and March 2011 with two different regimens of cytotoxic chemotherapy and three lines of multikinase inhibitors.<bold>Methods: </bold>Efficacy and adverse effects of the consecutive treatment modalities, i.e. vandetanib, doxorubicin-cisplatin combination, sorafenib, paclitaxel-carboplatin combination, and sunitinib, are reported.<bold>Results: </bold>The patient presented a complete tumor response to a doxorubicin-cisplatin combination lasting 10 months and to a paclitaxel-carboplatin regimen lasting 5 months and had no or limited response to kinase inhibitors, i.e. progression after 3 months of vandetanib, progression after 4 months of sorafenib, and stable disease for 8 months with sunitinib treatment.<bold>Conclusions: </bold>When tumor progresses with kinase inhibitors, cytotoxic chemotherapy may be an alternative in selected cases of advanced iodine-refractory poorly differentiated thyroid cancer. For those rare cases, clinical management should benefit from a multidisciplinary team approach through specialized networks.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2012, Vol 97, Issue 9, p3046
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2012-1630