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- Title
Biosynthesis and production of polysialic acids in bacteria.
- Authors
Ferrero, Miguel Ángel; Aparicio, Leandro Rodríguez
- Abstract
Polysialic acids (PA) are protective capsular sialohomopolymers present in some bacteria which can invade the mammalian host and cause lethal bacteremia and meningitis. Biosynthesis and translocation of PA to the cell surface are equivalent in different species and bacterial strains which are produced. The diversity in PA structure is derived from the PA linkages and is a consequence of the specific sialyltransferase activities. The monomer acetylation and the polymer length could be important factors in the potential virulence. In vivo PA production is affected by different physical and chemical factors. The temperature of cellular growth strictly regulates PA genesis through a molecular complex and multifactorial mechanism that operate to transcription level.
- Subjects
ESCHERICHIA coli; SIALIC acids; NEISSERIA meningitidis; BACTEREMIA in animals; MAMMAL diseases; BIOSYNTHESIS; BACTERIAL diseases in animals; BIOCHEMICAL engineering; BACTERIAL diseases
- Publication
Applied Microbiology & Biotechnology, 2010, Vol 86, Issue 6, p1621
- ISSN
0175-7598
- Publication type
Article
- DOI
10.1007/s00253-010-2531-5