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- Title
The CARET asbestos-exposed cohort: Baseline characteristics and comparison to other asbestos-exposed cohorts.
- Authors
Barnhart, Scott; Keogh, James; Cullen, Mark R.; Brodkin, Carl; Liu, Diane; Goodman, Gary; Valanis, Barbara; Glass, Andrew; Thornquist, Mark; Rosenstock, Linda; Omenn, Gilbert; Balmes, John
- Abstract
The Carotene and Retinol Efficacy Trial (CARET) was a double-blind, placebo-controlled trial of the daily administration of 25,000 IU vitamin A and 30 mg β-carotene for the prevention of lung cancer. Of close to 18,500 participants, more than 4,000 were asbestos-exposed men recruited from shipyard and construction trades at five study centers in the United States. While the primary endpoint of the trial was the incidence of lung cancer, a number of questions about the natural history of asbestos-related disease will also be addressed. The mean age at entry into the trial was 57 years and the mean duration of follow-up on active intervention was 4 years. With the exception of 133 never-smoker pilot participants (3%), all subjects recruited were by intention current (38%) or ex-smokers (58%), with a mean cumulative smoking exposure at entry of 43 pack-years. Mean years from first asbestos exposure were 35, and mean duration of asbestos exposure in a high-risk trade was 19 years. The distribution of radiographic abnormalities was as follows: normal, 34%; parenchymal opacities (ILO profusion score >1/0) alone, 18%; pleural thickening alone, 27%; both parenchymal opacities and pleural thickening, 21%. The CARET cohort, when compared to previously reported asbestos-exposed cohorts, is characterized by substantial asbestos exposure and high proportion of asbestos-related radiographic findings. The active intervention was halted in 1996, after a mean duration of 40 years. Passive follow-up of the cohort will continue until the year 2000. Am. J. Ind. Med. 32:573-581, 1997. © 1997 Wiley-Liss, Inc.
- Publication
American Journal of Industrial Medicine, 1997, Vol 32, Issue 6, p573
- ISSN
0271-3586
- Publication type
Article
- DOI
10.1002/(SICI)1097-0274(199712)32:6<573::AID-AJIM1>3.0.CO;2-R