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- Title
Nanopartículas: Un sistema de entrega de antifúngicos.
- Authors
Castrillón Rivera, Laura Estela; Palma Ramos, Alejandro; Castañeda Sánchez, Jorge Ismael; Espinosa Antúnez, Violeta
- Abstract
Introduction: The increase in the incidence of pathologies in which fungi appear as emerging pathogens is mainly associated with opportunistic fungi as well as susceptibility in patients with a certain degree of immunodeficiency because they present some risk factors such as neutropenia, diabetes, surgeries, abuse of antibiotic treatment, nosocomial diseases and transplant patients among others. To date, antifungal therapy is far from being ideal because in addition to resistance to antifungals, there is a limitation of their availability as a consequence of their toxicity, as well as the decrease in the effectiveness of the drug in free form, minimal restricted penetration. to tissues, decreased bioavailability, poor pharmacokinetics, lack of selectivity, severe side effects and low water solubility: Due to this situation, it is necessary to have new therapeutic measures that are efficient to combat mainly invasive mycoses, hence the objective of this review work to know the state of the art of the various antifungal delivery systems. Development of the topic: This bibliographic review addresses the following aspects related to: a) Types and structure of nanomaterials, b) Antifungal activity of nanoparticles and c) In vivo evaluation and cytotoxicity of nanoparticles. Conclusion: The development of new technologies and synthesis of nanomaterials emerges as a possible alternative for the treatment of fungal infections. In this work, the main advances related to nanomaterials designed as a possible delivery system for antifungals are presented.
- Publication
Revista Colombiana de Ciencias Químico-Farmacéuticas, 2024, Vol 53, Issue 2, p537
- ISSN
0034-7418
- Publication type
Article
- DOI
10.15446/rcciquifa.v53n2.114456