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A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-99880-y
By:
- Schumacher, David;
- Liehn, Elisa A.;
- Nilcham, Pakhwan;
- Mayan, David Castaño;
- Rattanasopa, Chutima;
- Anand, Kaviya;
- Crespo-Avilan, Gustavo E.;
- Hernandez-Resendiz, Sauri;
- Singaraja, Roshni R.;
- Cook, Stuart A.;
- Hausenloy, Derek J.
Publication type:
Article
P1-053: Alzheimer’s disease neuropathology is not mitigated by the physiological expression of human ABCA1 in APP/PS1 mice
Published in:
2006
By:
- Hirsch-Reinshagen, Veronica;
- Chan, Jeniffer Y.;
- McIsaac, Sean A.;
- Naus, Kathryn E.;
- Maia, Luis F.;
- Burgess, Braydon L.;
- Singaraja, Roshni R.;
- Hayden, Michael R.;
- Wellington, Cheryl L.
Publication type:
Abstract
P1-053: Alzheimer’s disease neuropathology is not mitigated by the physiological expression of human ABCA1 in APP/PS1 mice
Published in:
2006
By:
- Hirsch-Reinshagen, Veronica;
- Chan, Jeniffer Y.;
- McIsaac, Sean A.;
- Naus, Kathryn E.;
- Maia, Luis F.;
- Burgess, Braydon L.;
- Singaraja, Roshni R.;
- Hayden, Michael R.;
- Wellington, Cheryl L.
Publication type:
Abstract
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.
Published in:
Nature Genetics, 2002, v. 32, n. 2, p. 326, doi. 10.1038/ng957
By:
- Robitaille, Johane;
- MacDonald, Marcia L.E.;
- Kaykas, Ajamete;
- Sheldahl, Laird C.;
- Zeisler, Jutta;
- Dubé, Marie-Pierre;
- Zhang, Lin-Hua;
- Singaraja, Roshni R.;
- Guernsey, Duane L.;
- Zheng, Binyou;
- Siebert, Lee F.;
- Hoskin-Mott, Ann;
- Trese, Michael T.;
- Pimstone, Simon N.;
- Shastry, Barkur S.;
- Moon, Randall T.;
- Hayden, Michael R.;
- Goldberg, Y. Paul;
- Samuels, Mark E.
Publication type:
Article
Segregation of LIPG, CETP, and GALNT2 Mutations in Caucasian Families with Extremely High HDL Cholesterol.
Published in:
PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0037437
By:
- Tietjen, Ian;
- Hovingh, G. Kees;
- Singaraja, Roshni R.;
- Radomski, Chris;
- Barhdadi, Amina;
- Mcewen, Jason;
- Chan, Elden;
- Mattice, Maryanne;
- Legendre, Annick;
- Franchini, Patrick L.;
- Dubé, Marie-Pierre;
- Kastelein, John J. P.;
- Hayden, Michael R.;
- Schunkert, Heribert
Publication type:
Article
Low Levels of Human HIP14 Are Sufficient to Rescue Neuropathological, Behavioural, and Enzymatic Defects Due to Loss of Murine HIP14 in Hip14<sup>-/-</sup> Mice.
Published in:
PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0036315
By:
- Young, Fiona B.;
- Franciosi, Sonia;
- Spreeuw, Amanda;
- Yu Deng;
- Sanders, Shaun;
- Tam, Natalie C. M.;
- Kun Huang;
- Singaraja, Roshni R.;
- Weining Zhang;
- Bissada, Nagat;
- Kay, Chris;
- Hayden, Michael R.
Publication type:
Article
Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function.
Published in:
Journal of Neuroscience, 2009, v. 29, n. 11, p. 3579, doi. 10.1523/JNEUROSCI.4741-08.2009
By:
- Karasinska, Joanna M.;
- Rinninger, Franz;
- Lütjohann, Dieter;
- Ruddle, Piers;
- Franciosi, Sonia;
- Kruit, Janine K.;
- Singaraja, Roshni R.;
- Hirsch-Reinshagen, Veronica;
- Jianjia Fan;
- Brunham, Liam R.;
- Bissada, Nagat;
- Ramakrishnan, Rajasekhar;
- Wellington, Cheryl L.;
- Parks, John S.;
- Hayden, Michael R.
Publication type:
Article
Synaptic Imbalance, Stereotypies, and Impaired Social Interactions in Mice with Altered Neuroligin 2 Expression.
Published in:
Journal of Neuroscience, 2008, v. 28, n. 24, p. 6055, doi. 10.1523/JNEUROSCI.0032-08.2008
By:
- Hines, Rochelle M.;
- Longjun Wu;
- Hines, Dustin J.;
- Steenland, Hendrik;
- Mansour, Souraya;
- Dahlhaus, Regina;
- Singaraja, Roshni R.;
- Xiaoyan Cao;
- Sammler, Esther;
- Hormuzdi, Sheriar G.;
- Min Zhuo;
- El-Husseini, Alaa
Publication type:
Article
Bile Acids: A Communication Channel in the Gut-Brain Axis.
Published in:
NeuroMolecular Medicine, 2021, v. 23, n. 1, p. 99, doi. 10.1007/s12017-020-08625-z
By:
- Monteiro-Cardoso, Vera F.;
- Corlianò, Maria;
- Singaraja, Roshni R.
Publication type:
Article
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.
Published in:
FASEB Journal, 2018, v. 32, n. 7, p. 3792, doi. 10.1096/fj.201701084RR
By:
- Chevre, Raphael;
- Trigueros-Motos, Laia;
- Castaño, David;
- Chua, Tricia;
- Corlianò, Maria;
- Patankar, Jay V.;
- Sng, Lareina;
- Sim, Lauren;
- Tan Liang Juin;
- Carissimo, Guillaume;
- Ng, Lisa F. P.;
- Cheryl Neo Jia Yi;
- Eliathamby, Chelsea Chandani;
- Groen, Albert K.;
- Hayden, Michael R.;
- Singaraja, Roshni R.
Publication type:
Article
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
Published in:
Human Molecular Genetics, 2014, v. 23, n. 15, p. 4142, doi. 10.1093/hmg/ddu137
By:
- Butland, Stefanie L.;
- Sanders, Shaun S.;
- Schmidt, Mandi E.;
- Riechers, Sean-Patrick;
- Lin, David T.S.;
- Martin, Dale D.O.;
- Vaid, Kuljeet;
- Graham, Rona K.;
- Singaraja, Roshni R.;
- Wanker, Erich E.;
- Conibear, Elizabeth;
- Hayden, Michael R.
Publication type:
Article
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
Published in:
Human Molecular Genetics, 2013, v. 22, n. 3, p. 452, doi. 10.1093/hmg/dds441
By:
- Sutton, Liza M.;
- Sanders, Shaun S.;
- Butland, Stefanie L.;
- Singaraja, Roshni R.;
- Franciosi, Sonia;
- Southwell, Amber L.;
- Doty, Crystal N.;
- Schmidt, Mandi E.;
- Mui, Katherine K.N.;
- Kovalik, Vlad;
- Young, Fiona B.;
- Zhang, Weining;
- Hayden, Michael R.
Publication type:
Article
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
Published in:
Human Molecular Genetics, 2011, v. 20, n. 20, p. 3899, doi. 10.1093/hmg/ddr308
By:
- Singaraja, Roshni R.;
- Huang, Kun;
- Sanders, Shaun S.;
- Milnerwood, Austen J.;
- Hines, Rochelle;
- Lerch, Jason P.;
- Franciosi, Sonia;
- Drisdel, Renaldo C.;
- Vaid, Kuljeet;
- Young, Fiona B.;
- Doty, Crystal;
- Wan, Junmei;
- Bissada, Nagat;
- Henkelman, R. Mark;
- Green, William N.;
- Davis, Nicholas G.;
- Raymond, Lynn A.;
- Hayden, Michael R.
Publication type:
Article
Palmitoylation of huntingtin by HIP14is essential for its trafficking and function.
Published in:
Nature Neuroscience, 2006, v. 9, n. 6, p. 824, doi. 10.1038/nn1702
By:
- Yanai, Anat;
- Kun Huang;
- Rujun Kang;
- Singaraja, Roshni R.;
- Arstikaitis, Pamela;
- Lu Gan;
- Orban, Paul C.;
- Mullard, Asher;
- Cowan, Catherine M.;
- Raymond, Lynn A.;
- Drisdel, Renaldo C.;
- Green, William N.;
- Ravikumar, Brinda;
- Rubinsztein, David C.;
- El-Husseini, Alaa;
- Hayden, Michael R.
Publication type:
Article
Accurate Prediction of the Functional Significance of Single Nucleotide Polymorphisms and Mutations in the ABCA1 Gene.
Published in:
PLoS Genetics, 2005, v. 1, n. 6, p. e83, doi. 10.1371/journal.pgen.0010083
By:
- Brunham, Liam R.;
- Singaraja, Roshni R.;
- Pape, Terry D.;
- Kejariwal, Anish;
- Thomas, Paul D.;
- Hayden, Michael R.
Publication type:
Article
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
Published in:
Human Molecular Genetics, 2008, v. 17, n. 15, p. 2390, doi. 10.1093/hmg/ddn139
By:
- Warby, Simon C.;
- Doty, Crystal N.;
- Graham, Rona K.;
- Carroll, Jeffrey B.;
- Yang, Yu-Zhou;
- Singaraja, Roshni R.;
- Overall, Christopher M.;
- Hayden, Michael R.
Publication type:
Article
Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.
Published in:
Human Molecular Genetics, 2007, v. 16, n. 18, p. 2187, doi. 10.1093/hmg/ddm170
By:
- Valenza, Marta;
- Carroll, Jeffrey B.;
- Leoni, Valerio;
- Bertram, Lisa N.;
- Björkhem, Ingeman;
- Singaraja, Roshni R.;
- Di Donato, Stefano;
- Lutjohann, Dieter;
- Hayden, Michael R.;
- Cattaneo, Elena
Publication type:
Article
Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.
Published in:
Human Molecular Genetics, 2005, v. 14, n. 11, p. 1569, doi. 10.1093/hmg/ddi165
By:
- Warby, Simon C.;
- Chan, Edmond Y.;
- Metzler, Martina;
- Gan, Lu;
- Singaraja, Roshni R.;
- Crocker, Susan F.;
- Robertson, Harold A.;
- Hayden, Michael R.
Publication type:
Article
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Published in:
Human Molecular Genetics, 2002, v. 11, n. 23, p. 2815, doi. 10.1093/hmg/11.23.2815
By:
- Singaraja, Roshni R.;
- Hadano, Shinji;
- Metzler, Martina;
- Givan, Scott;
- Wellington, Cheryl L.;
- Warby, Simon;
- Yanai, Anat;
- Gutekunst, Claire-Anne;
- Leavitt, Blair R.;
- Yi, Hong;
- Fichter, Keith;
- Gan, Lu;
- McCutcheon, Krista;
- Chopra, Vikramjit;
- Michel, Jennifer;
- Hersch, Steven M.;
- Ikeda, Joh-E;
- Hayden, Michael R.
Publication type:
Article
Stem cell-derived polarized hepatocytes.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15337-2
By:
- Dao Thi, Viet Loan;
- Wu, Xianfang;
- Belote, Rachel L.;
- Andreo, Ursula;
- Takacs, Constantin N.;
- Fernandez, Joseph P.;
- Vale-Silva, Luis Andre;
- Prallet, Sarah;
- Decker, Charlotte C.;
- Fu, Rebecca M.;
- Qu, Bingqian;
- Uryu, Kunihiro;
- Molina, Henrik;
- Saeed, Mohsan;
- Steinmann, Eike;
- Urban, Stephan;
- Singaraja, Roshni R.;
- Schneider, William M.;
- Simon, Sanford M.;
- Rice, Charles M.
Publication type:
Article
1714-P: Absence of CYP8B1 Increases Insulin Sensitivity in Part via Modulation of the Gut Microbiome.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1714-P
By:
- CORLIANÒ, MARIA;
- ZHONG, SHIQI;
- SINGARAJA, ROSHNI R.
Publication type:
Article
Loss of Cyp8b1 Improves Glucose Homeostasis by Increasing GLP-1.
Published in:
Diabetes, 2015, v. 64, n. 4, p. 1168, doi. 10.2337/db14-0716
By:
- Kaur, Achint;
- Patankar, Jay V.;
- de Haan, Willeke;
- Ruddle, Piers;
- Wijesekara, Nadeeja;
- Groen, Albert K.;
- Verchere, C. Bruce;
- Singaraja, Roshni R.;
- Hayden, Michael R.
Publication type:
Article

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