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- Title
Prospective randomized trial of neoadjuvant chemotherapy during the 'wait period' following preoperative chemoradiotherapy for rectal cancer: results of the WAIT trial.
- Authors
Moore, J.; Price, T.; Carruthers, S.; Selva‐Nayagam, S.; Luck, A.; Thomas, M.; Hewett, P.
- Abstract
Aim The aim was to determine whether the addition of additional cycles of chemotherapy during the 'wait period' following neoadjuvant chemoradiotherapy for rectal cancer improves the pathological complete response ( pCR) rate. Method Rectal cancer patients were randomly allocated either to a standard 10 week wait period before surgery (standard chemoradiotherapy, SCRT) or to receive three cycles of fluorouracil based chemotherapy following chemoradiotherapy during a similar 10 week wait (extended chemoradiotherapy, XCRT). The primary end-point was pCR as determined by blinded pathological assessment. Results Forty-nine patients were randomized ( SCRT n = 24, XCRT n = 25). pCR occurred in 10 patients overall but there was no significant difference in pCR between the groups ( SCRT n = 6, XCRT n = 4, P = 0.49). Conclusion The addition of three cycles of 5-fluorouracil/leucovorin in a 10 week wait period after conventional chemoradiotherapy seems to result in similar pCR rates in patients with locally advanced rectal cancer based on this small randomized trial.
- Subjects
RECTAL cancer treatment; RECTAL cancer patients; CHEMORADIOTHERAPY; PREOPERATIVE care; SURGERY safety measures
- Publication
Colorectal Disease, 2017, Vol 19, Issue 11, p973
- ISSN
1462-8910
- Publication type
Article
- DOI
10.1111/codi.13724