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- Title
Natural history of hepatitis B virus–related cirrhotic patients hospitalized to control ascites.
- Authors
Seung Up Kim; Kwang-Hyub Han; Chung Mo Nam; Jun Yong Park; Do Young Kim; Chae Yoon Chon; Sang Hoon Ahn
- Abstract
Background and Aim: Few studies have assessed the natural history of hepatitis B virus (HBV)–related cirrhotic ascites. We investigated the natural history of patients with HBV-related cirrhotic ascites hospitalized to control ascites and determined their prognosis, including survival rates and prognostic factors affecting survival. Methods: Between January 1996 and December 2005, 203 consecutive patients with HBV-related cirrhotic ascites were followed for a median of 80.7 months (range, 15–149) after their first significant ascitic decompensation that required hospitalization. Results: The mean age of all patients was 52.6 years. Male gender predominated (male/female, 138/65). A subgroup analysis of 165 patients who had ascitic decompensation as their first episode of hepatic decompensation revealed that gastrointestinal variceal bleeding developed after a median interval of 8 months following ascitic decompensation in 31 (18.8%) patients, hepatic encephalopathy occurred at 9 months in 53 (32.1%), spontaneous bacterial peritonitis appeared at 12.7 months in 24 (14.5%), hepatorenal syndrome occurred at 8.1 months in five (3%), and hepatocellular carcinoma was observed at 21.2 months in 10 (6.1%). The overall median survival was 12.4 months. The 1- and 3-year survival rates were 50.7 and 18.7%. The prognostic factors that independently correlated with survival at the time of ascitic decompensation were Child–Pugh classification B/C ( P = 0.030), serum white blood cell (WBC; P = 0.035), serum creatinine (Cr; P = 0.039), serum sodium (Na; P = 0.010), and antiviral therapy ( P = 0.040). Conclusions: The prognosis of HBV-related cirrhotic patients with ascitic decompensation is poor. Child–Pugh class, serum WBC/Cr/Na, and antiviral therapy primarily influenced survival.
- Subjects
HEPATITIS B virus; CIRRHOSIS of the liver; ASCITES; HEPATIC encephalopathy; PROGNOSIS; ANTIVIRAL agents; PATIENTS
- Publication
Journal of Gastroenterology & Hepatology, 2008, Vol 23, Issue 11, p1722
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.2008.05510.x