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- Title
Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System Involvement.
- Authors
Mousinho, Filipa; Mendes, Tatiana; Sousa e Santos, Paula; Acosta, Maria João; Pereira, José; Arroz, Maria; Silva, Cândido; Azevedo, Ana Paula; Oliveira, Rita; Chorão, Martinha; Lima, Fernando
- Abstract
Early-stage chronic lymphocytic leukemia (CLL) with neurologic involvement is a rare condition and should require a careful follow-up. Although no standard protocol exists for this condition, intrathecal chemotherapy, combined with systemic chemoimmunotherapy, has been used previously. This case describes the treatment of a patient with CLL and symptomatic compromise of the central nervous system. Our results suggest that a combination of chemotherapy, radiotherapy, and ibrutinib, administered sequentially over a 2-year period, led to a near-complete resolution of the cerebral spinal fluid neoplastic infiltration. Importantly, this response has been maintained with ibrutinib monotherapy for more than 12 months.
- Subjects
LYMPHOCYTIC leukemia; CANCER chemotherapy; RADIOTHERAPY; CEREBROSPINAL fluid; NEOPLASTIC cell transformation
- Publication
Case Reports in Hematology, 2018, p1
- ISSN
2090-6560
- Publication type
Case Study
- DOI
10.1155/2018/7817918