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- Title
Immunohistochemical detection of HSP27 and hnRNP K as prognostic and predictive biomarkers for colorectal cancer.
- Authors
Wang, Feng; Zhang, Peng; Shi, Chenzhang; Yang, Yongzhi; Qin, Huanlong
- Abstract
The present study was aimed at evaluating the expression of heat shock protein 27 (HSP27) and heterogeneous nuclear ribonucleoprotein K (hnRNP K), two potential biomarkers of many cancers, in colorectal cancer (CRC) and their clinical significance. Expression of HSP27 and hnRNP K were investigated by immunohistochemistry (IHC) in a series of tissue microarrays containing 175 primary colorectal cancers and their corresponding normal mucosa samples and matched with clinicopathological features and patient survival. HSP27 and hnRNP K displayed more frequent strong immunoreactivity in primary colorectal tumor samples compared with adjacent non-cancer tissue ( P < 0.001). Increased cytoplasmic expression of HSP27 and hnRNP K were associated with tumor location ( P = 0.032 and P < 0.001, respectively), poorer overall survival ( P = 0.004 and P = 0.02, respectively) and to an unfavorable prognosis for CRC patients in multivariate analysis ( P = 0.019 and P = 0.01, respectively). Their overexpression combination identified a subset of patients with definitively worse prognosis than any other combination ( P < 0.001). Overexpression of HSP27 and hnRNPK were independent markers of poor prognosis, and their combination predicted definitively adverse outcomes in CRC patients.
- Subjects
COLON cancer; BIOMARKERS; IMMUNOHISTOCHEMISTRY; HEAT shock proteins; CANCER prognosis
- Publication
Medical Oncology, 2012, Vol 29, Issue 3, p1780
- ISSN
1357-0560
- Publication type
Article
- DOI
10.1007/s12032-011-0037-3