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- Title
Fractional anisotropy changes in the fornix and cingulum tracts in Alzheimer's disease continuum.
- Authors
Evin, Gözde Kızılateş; Harı, Emre; Bayram, Ali; Yıldız, Çiğdem Ulaşoğlu; Kurt, Elif; Acar, Burak; Demiralp, Tamer; Gürvit, İ. Hakan
- Abstract
Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease. Diffusion weighted MRI (D WI) changes were observed in disease-specific white matter (WM) tracts in the course of the disease, along which the neurofibrillary tangles spread transsynaptically. VVM changes may be important to follow the course of the disease. In this study, the tracts affected in AD continuum were investigated by using local DWI parameters. Methods: Multi-shell DWI from 15 AD dementia (ADD), 15 mild cognitive impairment (MCI) and 15 subjective cognitive impairment (SCI) subjects were obtained with 3T MRI device at the Neuroscience Unit of the Hulusi Behçet Life Sciences Research Laboratory of Istanbul University. In addition to the b=0 image, DWI data were recorded with 4 different b values (b=3000 s/mm2, b=1000 s/mm2, b=200 s/mm2, b=100 s/mm2) from a total of 120 directions. Tract-based spatial statistics (TBSS) based on fractional anisotropy (FA) values was performed using FSL 6.0.3 software (FMRIB Software Library). Three (fornix, ventral and dorsal cingulum) regions of interest (ROI) were determined according to Johns Hopkins University white matter atlas (JHU ICBM-DTI-81). Comparisons between 3 groups were performed by using one-way ANOVA and comparisons between pairs of groups by using t-tests. The significance threshold was set at p(FWE)<0.05. Results: Significant differences among the groups were obtained in the fornix and right ventral cingulum. FA decreased in the fornix and bilateral ventral cingulum in ADD compared to SCI. In addition, FA decreased in the fornix and right ventral cingulum in ADD compared to MCI. Conclusion: Our results show that diffusivity of the fomix and ventral cingulum, the main connection tracts of the Papez circuit that builds the neural infrastructure of the episodic memory, are impaired in AD continuum, and this impairment is associated with clinical severity.
- Subjects
JOHNS Hopkins University; ALZHEIMER'S disease; MILD cognitive impairment; DIFFUSION magnetic resonance imaging; NEUROFIBRILLARY tangles; ANISOTROPY
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2020, Vol 14, pS116
- ISSN
1307-8798
- Publication type
Article