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- Title
Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease.
- Authors
Saeed, Jehan; Saeed, Sally Mahmoud; Mohamed, Ali Irhoumah; Hamed, Mohamed Gaber
- Abstract
Background:Lower extremity arterial disease (LEAD) is a major endemic disease with an alarming increased prevalence worldwide and it is a major manifestation of systemic atherosclerosis with severe associated cardiovascular, lower limb and functional complications. The anklebrachial index (ABI) is a simple, non-invasive, widely used test that detects lower extremity arterial disease. Osteopontin (OPN) is a multifunctional protein independently discovered by investigators from diverse scientific backgrounds and implicated in a broad array of pathological process. Objective: This study aimed toinvestigate the differencesin ABI measurementsand serum OPN levels between type 2 diabetic (T2D) subjects with and without LEAD. Patients and Methods: This case control study was conducted at the Internal Medicine, Endocrinology Unit and Biochemistry Departments of Zagazig University Hospitals. 30 participants were classified into two groups. Group 1(n =30) healthy subjects (control), Group 2 (n =30) T2D diabetic subjects, who were further subdivided into two groups: 2A (n=15) T2D subjects with LEAD and 2B T2D subjects without LEAD. Measurement of Ankle brachial index madeby handheld doppler. Serum osteopontin levels were performed by ELISA kits. Results:Ankle brachial index measurements were significantly lower among diabetic with LEAD group compared to diabetic without LEAD group (p=0.000) and osteopontin values was higher in diabetic with LEAD than diabetic without LEAD group with highly significant results (p=0.000). Conclusion: The study concluded thatABI measurements and serum OPN levels have important value in detection of lower extremity arterial disease in subjects with type 2 diabetes mellitus.
- Subjects
ANKLE brachial index; ARTERIAL diseases; OSTEOPONTIN; TYPE 2 diabetes; ENDEMIC diseases
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2021, Vol 12, Issue 6, p191
- ISSN
0975-3583
- Publication type
Article