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- Title
The CD6 Scavenger Receptor Is Differentially Expressed on a CD56 Natural Killer Cell Subpopulation and Contributes to Natural Killer-Derived Cytokine and Chemokine Secretion.
- Authors
Braun, Monika; Müller, Bernadette; ter Meer, Dominik; Raffegerst, Silke; Simm, Barbara; Wilde, Susanne; Spranger, Stefani; Ellwart, Joachim; Mosetter, Barbara; Umansky, Ludmila; Lerchl, Tina; Schendel, Dolores J.; Falk, Christine S.
- Abstract
The CD6 scavenger receptor is known to be expressed on virtually all T cells and is supposed to be involved in costimulation, synapse formation, thymic selection and leukocyte migration. Here, we demonstrate that CD6 is differentially expressed by a subpopulation of peripheral CD56dim natu- ral killer (NK) cells and absent on CD56bright NK cells. CD56dimCD16+ cells represent the major NK subset in the periphery, and most cells within this group are positive for CD6. Most killer immunoglobulin-like receptor- and immunoglobulin-like transcript-positive cells also belong to the CD6+ subpopulation, as expected from their restricted expression on CD56dim NK cells. In addition, CD6+ NK cells are similar to the newly identified CD94lowCD56dim NK subpopulation and most distant from the recently defined CD27+ NK subpopulation based on the reverse correlation of expression between CD6 and CD27, a marker associated primarily with CD56bright NK cells. With respect to CD6 function on NK cells, direct CD6 triggering did not result in degranulation but induced secretion of cytokines (interferon-γ and tumor necrosis factor-α) and chemokines [CXCL10 (IP-10), CXCL1 (GRO-α)]. Thus, CD6 expression on peripheral NK cells marks a novel CD56dim subpopulation associated with distinct patterns of cytokine and chemokine secretion. Copyright © 2010 S. Karger AG, Basel
- Publication
Journal of Innate Immunity, 2011, Vol 3, Issue 4, p420
- ISSN
1662-811X
- Publication type
Article
- DOI
10.1159/000322720