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- Title
Efficacy of Siltuximab and 1,927 nm Fractional Laser for the Treatment of Cutaneous Manifestations in Castleman's Disease: The Role of Dermoscopy and Reflectance Confocal Microscopy for Lesion Evaluation.
- Authors
Paolino, Giovanni; Ardigò, Marco; Della-Torre, Emanuel; Moroni, Luca; Rizzo, Nathalie; Nicola, Matteo Riccardo Di; Bianchi, Vittoria Giulia; Dagna, Lorenzo; Ramirez, Giuseppe Alvise; Mercuri, Santo Raffaele
- Abstract
Introduction: Multicentric Castleman's disease (MCD) with cutaneous involvement has rarely been discussed in dermatologic literature, with few reports. Cutaneous lesions in MCD may induce deep scars, causing a significant impact in the daily life of the patients. The treatment of Castleman's disease (CD) is usually a challenge, especially in case of cutaneous involvement. Case Presentation: We report the case of a 35-year-old Caucasian man with a 3-year-old history of MCD with cutaneous involvement that we treated with a combined therapy characterized by siltuximab and 1,927 nm fractional laser. The patient showed a therapeutic response, characterized by a reduction of systemic symptoms and cutaneous manifestations. Conclusion: We believe that the combination of siltuximab and 1,927 nm fractional laser might have a synergistic beneficial role in patients with cutaneous iMCD and maximize esthetic outcomes. Anyway, additional evidence is needed to validate our findings.
- Subjects
CASTLEMAN'S disease; CUTANEOUS manifestations of general diseases; CONFOCAL microscopy; DERMOSCOPY; REFLECTANCE
- Publication
Case Reports in Dermatology, 2024, Vol 16, Issue 1, p97
- ISSN
1662-6567
- Publication type
Case Study
- DOI
10.1159/000536483