We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus.
- Authors
Robles-Cervantes, J. A.; Ramos-Zavala, M. G.; González-Ortiz, M.; Martínez-Abúndis, E.; Valencia-Sandoval, C.; Torres-Chávez, A.; Espinel-Bermúdez, C.; Santiago-Hernández, N. J.; Hernández-González, S. O.
- Abstract
To determine the relationship between serum concentrations of uric acid and insulin secretion with hyperglycaemic clamp technique among adults with type 2 diabetes mellitus (DM2) without hyperuricemia, we carried out a cross-sectional study on 45 patients of both gender. We observed correlation between uric acid with male gender r = 0.710 (P = 0.001). Also correlation between uric acid and total insulin secretion was positive r = 0.295 (P = 0.049). As well as a positive correlation adjusted for body mass index was demonstrated for the first, second, and total phases of insulin secretion, respectively, r = 0.438 (P = 0.022), r = 0.433 (P = 0.022), and r = 0.439 (P = 0.024). Serum concentration of uric acid showed a positive relationship with the total phase of insulin secretion; even in states prior to hyperuricemia, uric acid can play an important role in the function of the beta cell in patients with DM2.
- Subjects
TYPE 2 diabetes; SERUM; URIC acid; INSULIN; BODY mass index
- Publication
International Journal of Endocrinology, 2011, p1
- ISSN
1687-8337
- Publication type
Article
- DOI
10.1155/2011/107904