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- Title
Recommendations for standardized reporting of protein electrophoresis in Australia and New Zealand.
- Authors
Tate, Jillian; Caldwell, Grahame; Daly, James; Gillis, David; Jenkins, Margaret; Jovanovich, Sue; Martin, Helen; Steele, Richard; Wienholt, Louise; Mollee, Peter
- Abstract
Background: Although protein electrophoresis of serum (SPEP) and urine (UPEP) specimens is a well-established laboratory technique, the reporting of results using this important method varies considerably between laboratories. The Australasian Association of Clinical Biochemists recognized a need to adopt a standardized approach to reporting SPEP and UPEP by clinical laboratories. Methods: A Working Party considered available data including published literature and clinical studies, together with expert opinion in order to establish optimal reporting practices. A position paper was produced, which was subsequently revised through a consensus process involving scientists and pathologists with expertise in the field throughout Australia and New Zealand. Results: Recommendations for standardized reporting of protein electrophoresis have been produced. These cover analytical requirements: detection systems; serum protein and albumin quantification; fractionation into alpha-1, alpha-2, beta and gamma fractions; paraprotein quantification; urine Bence Jones protein quantification; paraprotein characterization; and laboratory performance, expertise and staffing. The recommendations also include general interpretive commenting and commenting for specimens with paraproteins and small bands together with illustrative examples of reports. Conclusions: Recommendations are provided for standardized reporting of protein electrophoresis in Australia and New Zealand. It is expected that such standardized reporting formats will reduce both variation between laboratories and the risk of misinterpretation of results.
- Subjects
AUSTRALIA; NEW Zealand; ELECTROPHORESIS; SERUM; URINE; PATHOLOGICAL laboratories
- Publication
Annals of Clinical Biochemistry, 2012, Vol 49, Issue 3, p242
- ISSN
0004-5632
- Publication type
Article
- DOI
10.1258/acb.2011.011158