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- Title
Antidepressant effect of Stillen™.
- Authors
Jeong, Hyun-Ja; Kim, Jeong-Hwa; Kim, Na-Rae; Yoou, Myoung-schook; Nam, Sun-Young; Kim, Kyu-Youb; Choi, Youngjin; Jang, Jae-Bum; Kang, In-Cheol; Baek, Nam-In; Kim, Hyung-Min
- Abstract
Stillen™ has been used to treat patients with gastric mucosal ulcers and has an anti-inflammatory effect. It is well-known that neuro-inflammatory reactions are related to depression. Here we evaluated the antidepressant-like effect of Stillen™ on mice subjected to the forced swimming test (FST). Stillen™ and eupatilin (a major component of Stillen™) significantly decreased immobility times compared with the FST control group. In the Stillen™-administered group, increased levels of 5-hydroxytryptamine (serotonin) and brain-derived neurotrophic factor protein were observed in the hippocampus. Nissl bodies also increased in the hippocampus neuronal cytoplasm of the Stillen™-administered group. Stillen™ decreased levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (at the mRNA and protein levels) in the hippocampus and serum, compared with the control group. In addition, the mRNA expression of estrogen receptor-β increased after Stillen™ administration in the hippocampus. These findings suggest that Stillen™ should be viewed as a candidate antidepressant.
- Publication
Archives of Pharmacal Research, 2015, Vol 38, Issue 6, p1223
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-014-0472-8