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- Title
Quality of Life in Patients with Benign Non-Toxic Goiter After Surgical Intervention: A Systematic Review and Meta-Analysis.
- Authors
Chaves, Natalia; Rodriguez, M. Juanita; Broekhuis, Jordan M.; Chen, Hao Wei; Bain, Paul A.; James, Benjamin C.
- Abstract
Background: Prior studies evaluating health-related quality of life (HR-QoL) outcomes in patients undergoing surgery for benign non-toxic goiter have used different instruments and time points, leading to conflicting results. We sought to systematically review the differences in HR-QoL among patients with BNTG at baseline and 6 months after surgery, using exclusively the ThyPRO questionnaire. Methods: A systematic search was performed using PubMed, Embase, Web of Science, Cochrane Central, CINAHL, and PsycINFO for papers reporting the assessment of HR-QoL utilizing ThyPRO. Data were meta-analyzed using a random-effects model, and pooled estimates were calculated using weighted mean differences (WMD) between baseline and 6 months after surgery. We assessed the quality and risk of bias of the studies using the Robins-I tool and previously published minimally important change (MIC) values to assess clinical significance. Results: Six papers met the predefined inclusion criteria, describing a total of 496 patients. Meta-analysis demonstrated improved QoL in all thirteen domains of ThyPRO six months post-surgical intervention compared to baseline. Specifically, the largest improvement in QoL was seen in the domains of overall QoL, WMD −25.84 (95% CI −29.70, −21.98, p < 0.001, I2 = 23%), goiter symptoms, 23.96 (95% CI −30.29, −17.64, p < 0.001, I2 = 91%), and tiredness, −16.20 (95% CI −19.23, −13.16, p < 0.001, I2 = 3%). The differences in scores 9 of 13 domains were clinically significant based on MIC. Conclusions: Disease-specific HR-QoL improved in all ThyPRO domains after surgery in patients with BNTG. Future studies of QoL in thyroid surgery patients will benefit from a standard questionnaire and improved reporting of covariates including complications to ensure comparability across studies.
- Subjects
GOITER; QUALITY of life; CINAHL database
- Publication
World Journal of Surgery, 2022, Vol 46, Issue 5, p1093
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-022-06452-w