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- Title
Glycemic Status and Prognosis of Patients with Squamous Cell Carcinoma of the Esophagus.
- Authors
Okamura, Akihiko; Watanabe, Masayuki; Imamura, Yu; Hayami, Masaru; Yamashita, Kotaro; Kurogochi, Takanori; Mine, Shinji
- Abstract
Background: The impact of glycemic status on esophageal squamous cell carcinoma (ESCC) prognosis is unclear. Methods: A total of 623 patients who underwent curative subtotal esophagectomy for ESCC were evaluated. Diabetes was defined as a prior diagnosis of diabetes under treatment or newly diagnosed diabetes based on preoperative glycosylated hemoglobin (HbA1c) levels. Poor glycemic control was defined as HbA1c ≥ 7.0%, whereas good glycemic control was defined as HbA1c < 7.0%. The impact of glycemic status on long-term survival after esophagectomy was evaluated. Results: Among the 623 patients, 64 (10.3%) had diabetes including 30 (4.8%) with poor glycemic control. Although diabetes did not influence patient survival, patients with poor glycemic control had worse overall and disease-specific survival compared with those with good glycemic control ( P = 0.011 and 0.039, respectively). Comparing poor glycemic control with good glycemic control, the hazard ratios (HRs) for overall and disease-specific mortality were 1.91 (1.15-3.18) and 1.89 (1.02-3.49) in univariate analysis. After multivariate adjustment, poor glycemic control also had increased risk of overall and disease-specific mortality [HR 1.72 (95% CI 1.02-2.88) and 1.65 (95% CI 0.89-3.08), respectively]. Poor glycemic control did not increase the risk of overall or disease-specific mortality in patients with stages 0-II disease but significantly increased this risk in those with stages III-IV disease [HR 2.05 (1.14-3.69) and 1.95 (1.01-3.80), respectively]. Conclusions: Poor glycemic control is an independent risk factor for overall and disease-specific mortality after esophagectomy for advanced-stage ESCC.
- Subjects
SQUAMOUS cell carcinoma; ESOPHAGECTOMY; DIABETES; GLYCOSYLATED hemoglobin; GLYCEMIC control
- Publication
World Journal of Surgery, 2017, Vol 41, Issue 10, p2591
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-017-4036-1