We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Fine-Needle Aspiration Biopsy of Benign Thyroid Nodules: An Evidence-Based Review.
- Authors
Lundgren, Catharina Ihre; Zedenius, Jan; Skoog, Lambert
- Abstract
Since the development of fine-needle aspiration biopsy (FNAB) techniques, preoperative diagnosis and subsequent strategies for patient treatment have changed and evolved greatly. This is true also for thyroid FNAB: the vast majority of thyroid nodules are benign, and hence do not necessarily require surgical treatment. A comprehensive Medline and Cochrane Library search was performed evaluating FNAB in the thyroid. In the last decade more than 400 articles on the subject have been published. Data in relation to the experience with FNAB at the Karolinska University Hospital since its introduction were also reviewed. The development of FNAB since the 1960s at the Karolinska University Hospital is described. During the period 1992–1996 the accuracy of the clinical routine was evaluated by studying the outcomes of almost 4,000 FNAs of the thyroid. The results were good, with only a few false-negative and false-positive results, but the problem of differentiating follicular adenoma from follicular carcinoma remained a significant problem. The use of immunological analysis has greatly increased the possibility of obtaining valuable information on cellular characteristics. A successful FNAB service rests on several factors, and the importance of clinical conferences between all specialists involved in the diagnosis and treatment of patients with thyroid disorders cannot be overemphasized. At the Karolinska University Hospital there are weekly conferences where patients are discussed both pre- and postoperatively. These conferences lead to optimal interaction between the different specialists and, most important, substantial improvement in the clinical management of patients with thyroid disorders.
- Subjects
NEEDLE biopsy; THYROID diseases; CANCER; MEDLINE; ADENOMA; EVIDENCE-based medicine; SYSTEMATIC reviews
- Publication
World Journal of Surgery, 2008, Vol 32, Issue 7, p1247
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-008-9578-9