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- Title
Vascular involvement in Behçet's disease: the immunopathological process.
- Authors
Machado de Vargas, Raquelle; Nunes da Cruz, Maria Luiza; Hashimoto Giarllarielli, Maria Paula; Mota Sano, Beatriz; Idelfoncio da Silva, Geovana; Furlani Zoccal, Karina; Tefé-Silva, Cristiane
- Abstract
Behçet's disease is a rare form of systemic vasculitis that affects small to large vessels. It is characterized by mucocutaneous, pulmonary, cardiovascular, gastrointestinal, and neurological manifestations. Its clinical presentation is quite wide, ranging from milder cases to severe cases, with multisystemic involvement, characteristically with exacerbations and remissions. Its etiopathogenesis is still unclear, although there is evidence of genetic, environmental, and immunological factors, such as the association with the HLA-B51 allele. In conjunction, all of these point to an abnormal immunopathological process, with activation of cells of innate and adaptive immunity, such as NK cells, neutrophils, and T cells, which generate specific response patterns and cytokines capable of generating mediators that can damage and inflame blood vessels, resulting in venous and arterial occlusions and/or aneurysm formation.
- Subjects
BEHCET'S disease; KILLER cells; NATURAL immunity; ARTERIAL occlusions; T cells; TAKAYASU arteritis
- Publication
Jornal Vascular Brasileiro, 2021, Vol 20, p1
- ISSN
1677-5449
- Publication type
Case Study
- DOI
10.1590/1677-5449.200170