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- Title
Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus.
- Authors
Kanafani, Zeina A.; Klepser, Michael E.
- Abstract
Aminocandin is a new broad-spectrum echinocandin. The activity of this new agent was compared with amphotericin B (AmB), itraconazole, and caspofungin in a murine model of disseminated aspergillosis. Three Aspergillus fumigatus isolates were used, two fully susceptible (AF293 and A1163) and one resistant to itraconazole (AF91). Mice were made temporari or persistently neutropenic and were infected via intravenous inoculation. After 11days, organs were harvested for quantative culture. Following infection with AF293, 100% of the temporarily neutropenic mice treated with intravenous aminocandin 5 mg/kg survive Regimens of aminocandin 1 mg/kg, AmB 5 mg/kg and itraconazole 25 mg/kg provided similar outcom (p>0.05). Against AF91, treatment with aminocand 5 mg/kg and 1 mg/kg, in the temporarily neutropenic model, both resulted in 100% survival. In the persistently neutropenic model, following infection with A1163, the aminocandin, caspofungin, and micafungin all prolonge survival and reduced fungal burden compared with treatment (control mice). However, only aminocandin 5 mg/kg resulted in organ sterilization in 40% and 50% of mice infected with AF293 and AF91, respectively.
- Subjects
AMPHOTERICIN B; ASPERGILLOSIS; ASPERGILLUS fumigatus; LABORATORY mice; NEUTROPENIA; MYCOSES
- Publication
Journal of Invasive Fungal Infections, 2010, Vol 4, Issue 2, p72
- ISSN
1753-3783
- Publication type
Article