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- Title
An 8‐Year‐Old Girl with Posterior Fossa Mass.
- Authors
Ruf, Viktoria C.; Schöler, Anne; Capper, David; Arzberger, Thomas; Herms, Jochen; Schüller, Ulrich
- Abstract
Both tumors underwent 450K-methylation analysis that identified posterior fossa ependymomas, group A (EPN PFA) (0.67 (1) and 0.99 (2), respectively), which have aggressive behavior and bad outcomes. Therefore, the 450K-methylation profiling strongly suggests that the initial manifestation represented like the second one an anaplastic ependymoma and not a medulloblastoma, thus prompting to consider methylation profiling for all pediatric small blue round cell tumors. Still, this case emphasizes the relevance and importance of molecular analyses of pediatric brain tumors as (1) histological assessment only can be misleading, particularly in small blue round cell tumors and (2) different tumor entities in the same patient can be clearly distinguished.
- Subjects
CELL tumors; INFRATENTORIAL brain tumors; GLIOMAS; MOLECULAR pathology; BRAIN tumors; MENINGES
- Publication
Brain Pathology, 2020, Vol 30, Issue 3, p713
- ISSN
1015-6305
- Publication type
Article
- DOI
10.1111/bpa.12833