We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Erythrocyte antioxidant enzyme activities in children with myelomeningocele.
- Authors
Graf, William D.; Pippenger, C. E.; Shurtleff, David B.; Graf, W D; Shurtleff, D B
- Abstract
Erythrocyte free radical scavenging enzyme activities and their cofactor trace elements in plasma were assessed in 26 selected patients with myelomeningocele, both parents from 10 selected families, and 14 healthy adult controls. All index children except one were deficient in erythrocyte glutathione peroxidase (GSH-Px). Nine of 10 parent pairs had at least one parent with deficient GSH-Px activity. Children with myelomeningocele had significantly lower GSH-Px activities than their parents; the group of 10 parent pairs had significantly lower GSH-Px activities than the control group; and glutathione reductase activities were significantly lower in parents and children with myelomeningocele compared with controls. A deficiency in one or more antioxidant enzymes may increase the risk for neural tube defects.
- Publication
Developmental Medicine & Child Neurology, 1995, Vol 37, Issue 10, p900
- ISSN
0012-1622
- Publication type
journal article
- DOI
10.1111/j.1469-8749.1995.tb11942.x