We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Ameliorating effects of antioxidative compounds from four plant extracts in experimental models of diabetes.
- Authors
DINIĆ, SVETLANA; USKOKOVIĆ, ALEKSANDRA; MIHAILOVIĆ, MIRJANA; GRDOVIĆ, NEVENA; ARAMBAŠIĆ, JELENA; MARKOVIĆ, JELENA; POZNANOVIĆ, GORAN; VIDAKOVIĆ, MELITA
- Abstract
Given that oxidative stress plays a major role in pancreatic β-cell dysfunction and ultimate destruction, as well as in different complications of diabetes, therapy with antioxidants has assumed an important place in the management of diabetes. The relatively limited effects of established antioxidant compounds have stimulated efforts to develop new therapeutic strategies, e.g. to increase the endogenous antioxidant defences through pharmacological modulation of key antioxidant enzymes. Plant extracts are gaining popularity in treating diabetes because many substances synthesized by higher plants and fungi possess antioxidant activities and can prevent or protect tissues against the damaging effects of free radicals. This review summarizes experimental models of diabetes and possible mechanisms that lie behind the antioxidative effects of á-lipoic acid (LA), a powerful antioxidant and compound that stimulates cellular glucose uptake, as well as of plant extracts from sweet chestnut (Castanea sativa), edible mushroom (Lactarius deterrimus) and natural products containing β-glucans in the treatment of diabetes. Their roles in preventing pancreatic β-cell death and in ameliorating the effects of severe diabetic complications are discussed.
- Subjects
TREATMENT of diabetes; OXIDATIVE stress; ANTIOXIDANTS; PLANT extracts; MATHEMATICAL models; PANCREATIC beta cells; LIPOIC acid; EDIBLE mushrooms
- Publication
Journal of the Serbian Chemical Society, 2013, Vol 78, Issue 3, p365
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC121026136D