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- Title
Effectiveness of a 23-valent pneumococcal polysaccharide vaccine for the prevention of pneumococcal pneumonia in the elderly with chronic respiratory diseases: a case-control study of a single center.
- Authors
Masuda, Toshihiro; Nakatani, Eiji; Shirai, Toshihiro; Akamatsu, Taisuke; Tamura, Kanami; Takahashi, Shingo; Tanaka, Yuko; Watanabe, Hirofumi; Endo, Yoshinari; Suzuki, Takahito; Saigusa, Mika; Yamamoto, Akito; Morita, Satoru; Sato, Yoko; Asada, Kazuhiro
- Abstract
<bold>Background: </bold>The effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in preventing pneumococcal pneumonia has been controversial.<bold>Methods: </bold>To evaluate the effectiveness of the PPSV23 in elderly outpatients with chronic respiratory diseases, we carried out a case-control study, including 4128 outpatients aged ≥ 65 years, in the respiratory department.<bold>Results: </bold>There were 320 vaccinated patients, of which 164 were diagnosed with pneumococcal pneumonia. The adjusted odds ratio was 0.39 (95% confidence interval (CI), 0.17 to 0.89). In the subsets consisting of age groups ≥ 70 and ≥ 75 years, the adjusted odds ratio (95% CI) was respectively 0.16 (0.04 to 0.67) and 0.15 (0.02 to 1.12).<bold>Conclusion: </bold>This real-world study suggests that PPSV23 can be useful in preventing pneumococcal pneumonia in the elderly with chronic respiratory diseases.
- Subjects
PNEUMOCOCCAL pneumonia; PNEUMOCOCCAL vaccines; RESPIRATORY diseases; CHRONIC diseases; OLDER people
- Publication
BMC Pulmonary Medicine, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2466
- Publication type
journal article
- DOI
10.1186/s12890-021-01491-w