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- Title
The relationship of vascular endothelial growth factor gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX: VEGF polymorphism in gastric cancer.
- Authors
Oh, Sung Yong; Kwon, Hyuk-Chan; Kim, Sung Hyun; Lee, Suee; Lee, Ji Hyun; Hwang, Jung-Ah; Hong, Seung Hyun; Graves, Christian A; Camphausen, Kevin; Kim, Hyo-Jin; Lee, Yeon-Su
- Abstract
<bold>Background: </bold>The aim of this study is to evaluate the associations between vascular endothelial growth factor (VEGF) Single-nucleotide polymorphisms (SNPs) and clinical outcome in advanced gastric cancer patients treated with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX).<bold>Methods: </bold>Genomic DNA was isolated from whole blood, and six VEGF (-2578C/A, -2489C/T, -1498 T/C, -634 G/C, +936C/T, and +1612 G/A) gene polymorphisms were analyzed by PCR. Levels of serum VEGF were measured using enzyme-linked immunoassays.<bold>Results: </bold>Patients with G/G genotype for VEGF -634 G/C gene polymorphism showed a lower response rate (22.2%) than those with G/C or C/C genotype (32.3%, 51.1%; P = 0.034). Patients with the VEGF -634 G/C polymorphism G/C + C/C genotype had a longer progression free survival (PFS) of 4.9 months, compared with the PFS of 3.5 months for those with the G/G (P = 0.043, log-rank test). By multivariate analysis, this G/G genotype of VEGF -634 G/C polymorphism was identified as an independent prognostic factor (Hazard ratio 1.497, P = 0.017).<bold>Conclusion: </bold>Our data suggest that G/G genotype of VEGF -634 G/C polymorphism is related to the higher serum levels of VEGF, and poor clinical outcome in advanced gastric cancer patients.
- Publication
BMC Cancer, 2013, Vol 13, Issue 1, p43
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/1471-2407-13-43