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- Title
Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy.
- Authors
Tanaka, Mototsugu; Seki, George; Someya, Tomonosuke; Nagata, Michio; Fujita, Toshiro
- Abstract
Predominant or codominant immunoglobulin (Ig) A deposition in the glomerular mesangium characterizes IgA nephropathy (IgAN). Accumulated glomerular IgA is limited to the IgA1 subclass and usually galactose-deficient. This underglycosylated IgA may play an important role in the pathogenesis of IgAN. Recently, antibodies against galactose-deficient IgA1 were found to be well associated with the development of IgAN. Several therapeutic strategies based on corticosteroids or other immunosuppressive agents have been shown to at least partially suppress the progression of IgAN. On the other hand, several case reports of kidney transplantation or acquired IgA deficiency uncovered a remarkable ability of human kidney to remove mesangial IgA deposition, resulting in the long-term stabilization of kidney function. Continuous exposure to circulating immune complexes containing aberrantly glycosylated IgA1 and sequential immune response seems to be essential in the disease progression of IgAN. Removal of mesangial IgA deposition may be a challenging, but fundamental approach in the treatment of IgAN.
- Subjects
IMMUNOGLOBULIN A; GLOMERULAR filtration rate; KIDNEY diseases; ADRENOCORTICAL hormones; GALACTOSE
- Publication
Clinical & Developmental Immunology, 2011, p1
- ISSN
1740-2522
- Publication type
Article
- DOI
10.1155/2011/470803