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- Title
Synthesis and Cardiotropic Activity of Cyclic Methoxyphenyltriazaalkanes.
- Authors
Mokrov, G. V.; Likhosherstov, A. M.; Barchukov, V. V.; Stolyaruk, V. N.; Tsorin, I. B.; Vititnova, M. B.; Rebeko, A. G.; Kryzhanovskii, S. A.; Gudasheva, T. A.
- Abstract
A new group of compounds – 1-(methoxybenzyl)-4-[2-((methoxybenzyl)amino)ethyl]piperazin-2,3-diones was synthesized. As compared with previously studied linear methoxyphenyltriazaalkanes, the structure of the triazaalkane linker was found to influence the cardiotropic actions of the corresponding compounds. The most effective among the new group was 1-(2,4-dimethoxybenzyl)-4{2-[2,4-dimethoxybenzyl)amino]ethyl}piperazin-2,3-dione, which had significant antiarrhythmic activity at a dose of 2 mg/kg in a calcium chloride arrhythmia model, along with activity at the level of a tendency in models of aconitin arrythmia and reperfusion ventricular fibrillation.
- Subjects
VENTRICULAR arrhythmia; CALCIUM chloride; ARRHYTHMIA
- Publication
Pharmaceutical Chemistry Journal, 2019, Vol 53, Issue 7, p598
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-019-02045-5