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- Title
α-Thalassaemia trait is associated with Antibody prevalence against Malaria Antigens AMA-1 and MSP-1.
- Authors
Daou, Modibo; Kituma, Elimsaada; Kavishe, Reginald; Chilongola, Jaffu; Mosha, Frank; van der Ven, André; Kouriba, Bourema; Bousema, Teun; Sauerwein, Robert; Doumbo, Ogobaro
- Abstract
A longitudinal study was conducted in a low endemic area in northern Tanzania to examine the influence of the a-thalassaemia trait on malaria incidence and antibody responses to malaria apical membrane antigen-1 (AMA-1) and merozoite surface protein 1-19 (MSP-119). Out of 394 children genotyped for α-thalassaemia trait, 4.1% (16 of 394) and 30.7% (121 of 394) were homozygous and heterozygous, respectively. During the 1 year follow-up, four incidents of malaria cases were detected without an evident association with a-thalassaemia. Being heterozygous or homozygous for a-thalassaemia was associated with an increased prevalence of antibodies to AMA-1 [odds ratio (OR): 1.83, 95% confidence interval (CI): 1.07-3.12, p¼0.027] and MSP-1 (OR: 2.04, 95% CI: 1.16-3.60, p¼0.013) after adjustment for age and reported bednet use. The observed association between a-thalassaemia and malaria antibody responses may reflect longer-term differences in antigen exposure or differences in antibody acquisition upon exposure in this low endemic setting.
- Subjects
TANZANIA; THALASSEMIA diagnosis; ANTIMALARIALS; THALASSEMIA treatment; APICAL membrane antigen 1; MEROZOITES
- Publication
Journal of Tropical Pediatrics, 2015, Vol 61, Issue 2, p139
- ISSN
0142-6338
- Publication type
Article
- DOI
10.1093/tropej/fmu077