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- Title
The Network Library: a framework to rapidly integrate network biology resources.
- Authors
Summer, Georg; Kelder, Thomas; Radonjic, Marijana; van Bilsen, Marc; Wopereis, Suzan; Heymans, Stephane
- Abstract
Motivation: Much of the biological knowledge accumulated over the last decades is stored in different databases governed by various organizations and institutes. Integrating and connecting these vast knowledge repositories is an extremely useful method to support life sciences research and help formulate novel hypotheses. Results: We developed the Network Library (NL), a framework and toolset to rapidly integrate different knowledge sources to build a network biology resource that matches a specific research question. As a use-case we explore the interactions of genes related to heart failure with miRNAs and diseases through the integration of 6 databases.
- Subjects
LIFE sciences; SYSTEMS biology; BIOLOGICAL systems; MOLECULAR biology; BIOINFORMATICS
- Publication
Bioinformatics, 2016, Vol 32, Issue 17, pi473
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btw436